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American Zoologist 1973 13(3):613-623; doi:10.1093/icb/13.3.613
© 1973 by The Society for Integrative and Comparative Biology
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Glucagon: An Incomplete and Biased Review with Selected References1

PIERO P. FOÀ
Department of Research, Sinai Hospital of Detroit Detroit, Michigan 48235

This review summarizes the biochemistry, mode of action, physiologic functions, and clinical usefulness of glucagon, with emphasis on its role as a mobilizer of glycogen and fat, when adequate amount of exogenous nutrients are unavailable (starvation, heavy exercise, neonatal state) or cannot be properly utilized (diabetes mellitus). The "anti-insulin" properties of glucagon and the lessons of comparative physiology are reviewed.


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