© 1973 by The Society for Integrative and Comparative Biology
Glucagon: An Incomplete and Biased Review with Selected References1
Department of Research, Sinai Hospital of Detroit Detroit, Michigan 48235
This review summarizes the biochemistry, mode of action, physiologic functions, and clinical usefulness of glucagon, with emphasis on its role as a mobilizer of glycogen and fat, when adequate amount of exogenous nutrients are unavailable (starvation, heavy exercise, neonatal state) or cannot be properly utilized (diabetes mellitus). The "anti-insulin" properties of glucagon and the lessons of comparative physiology are reviewed.