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American Zoologist 1973 13(3):823-838; doi:10.1093/icb/13.3.823
© 1973 by The Society for Integrative and Comparative Biology
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The Renin-Angiotensin System in Fishes

HIROKO NISHIMURA and MIZUHO OGAWA
Department of Pharmacology, College of Physicians and Surgeons of Columbia University New York, New York 10032
Department of Biology, Saitama University Urawa, 336 Japan

It has been suggested that the renin-angiotensin system (RAS) in mammals may participate in the control of blood pressure, regulation of aldosterone secretion, or in renal functions by influencing intrarenal hemodynamics, or possibly by directly altering renal tubular sodium reabsorption. Comparative studies have shown that this system is present among most vertebrates. Renal renin activity and juxtaglomerular cells (JGC), the possible site of formation and accumulation of renin, have not been found in the cyclostomes and elasmobranchs. They seem to have evolved in primitive bony fishes, being present in all living groups of actinopterygians and sarcopterygians. Both renin and JGC may also exist in a holocephalian, the ratfish, Hydrolagus colliei. The functions of the RAS are not yet denned in fishes. There is no clear evidence for sodium retaining function of the RAS in fishes. Fish angiotensins (angiotensin-like substances) have chemical properties that differ from those of mammals and other tetrapods. It is possible that they also serve quite different functions in fishes than in mammals.


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