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American Zoologist 1973 13(4):1061-1065; doi:10.1093/icb/13.4.1061
© 1973 by The Society for Integrative and Comparative Biology
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Hyaluronate and Hyaluronidase in Morphogenesis and Differentiation

BRYAN P. TOOLE
Developmental Biology Laboratory, Departments of Medicine and Biological Chemistry, Harvard Medical School and Massachusetts General Hospital Boston, Massachusetts 02114

Hyaluronate turnover is correlated with morphogenetic events during chondrogenesis in the regenerating newt limb and in the chick embryo limb and axial preskeleton and during development of the chick embryo cornea. In vitro hyaluronate, in concentrations as low as 1 ng/ml, blocks the formation of cartilage—like aggregates in high density stationary cultures of stage 26 chick embryo somite cells. This inhibition is prevented by hormones known to promote skeletal development and by adenosine 3',5'cyclic monophosphate.

An hypothesis is discussed in which (1) hyaluronate may interfere with cell interactions leading to aggregation, encapsulation by matrix and consequent immobilization and (2) hyaluronate turnover could provide a means of timing of morphogenetic events such as cell migrations, allowing sufficient accumulation of cells prior to overt differentiated tissue formation.


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