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American Zoologist 1975 15(1):209-221; doi:10.1093/icb/15.1.209
© 1975 by The Society for Integrative and Comparative Biology
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Development of Immunity and the Concept of Stem Cell Tolerance

ROBERT AUERBACH
Department of Zoology, University of Wisconsin Madison, Wisconsin, 53706

Evidence is presented which indicates that differentiation of immunocompetence is achieved early in development, with some aspects of the immune system maturing concomitant with the appearance of blood-borne cells and thymic lymphocytes. Experiments are described which show that long-lasting, serum-mediated unresponsiveness to heterologous erythrocytes can be induced by injection of soluble factors released from such erythrocytes. These two lines of investigation lead to the hypothesis that tolerance may be achieved during development by the release, from various stem cells, of soluble factors which induce in the developing embryo a series of blocking factors. These factors subsequently are effective in preventing immune recognition net only of the stem cells themselves but also of their differentiated progeny.


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