Skip Navigation

American Zoologist 1975 15(1):63-71; doi:10.1093/icb/15.1.63
© 1975 by The Society for Integrative and Comparative Biology
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by MANNING, M. J.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

The Phylogeny of Thymic Dependence

MARGARET J. MANNING
Department of Zoology, University of Hull Hull, HU6 7RX, England

Thymic dependence has been studied in the clawed toad,Xenopus laevis. Examination of toadlets thymectomized as larvae at 8 days post-fertilization shows that: (i) The body weights are normal; (ii) The spleen is smaller than normal and there are fewer lymphocytes in the red pulp; (iii) There is an overall suppression of specific antibody, including all IgM, following immunization with human gamma globulin (HGG) in adjuvant or with sheep erythrocytes (SRBC); (iv) Stimulation using HGG elicits some splenic pyroninophilia but the spleens are less reactive than in controls; (v) The normal pattern of HGG localization in the splenic white pulp is absent; (vi) There is an increased susceptibility to Mycobacterium marinum; (vii) Serum immunoglobulin levels and the amounts of surface-associated immunoglobulin on splenic cells are increased; (viii) First-set rejection of skin allografts is prolonged but eventually goes to completion. These findings are discussed both in relation to the role of the thymus in the dichotomy of cell-mediated and humoral immune responses and in a phylogenetic context.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.