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American Zoologist 1975 15(2):249-256; doi:10.1093/icb/15.2.249
© 1975 by The Society for Integrative and Comparative Biology
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Regulation of Prolactin and Growth Hormone Production by Clonal Strains of Functional Pituitary Cells in Culture

JOEL L. IVEY and ARMEN H. TASHJIAN, JR.
Laboratory of Pharmacology, Harvard School of Dental Medicine and Department of Pharmacology Harvard Medical School, Boston, Massachusetts 02115

This report describes the use of clonal strains of rat pituitary tumor cells to study the regulation of prolactin and growth hormone production. Emphasis is placed on the effects on prolactin production of the hypothalamic tripeptide pGlu-His-ProNH2, also called thyrotropin releasing hormone (TRH). TRH binds to specific cellular receptors and stimulates initially the release of previously synthesized prolactin; several hours later it stimulates the synthesis of prolactin. Several kinds of experimental results are consistent with the hypothesis that cyclic AMP mediates the TRH-stimuIated release of prolactin. However, all of the effects of TRH on these cells in culture are not mimicked by cyclic AMP analogs, for TRH decreases growth hormone production while it increases the synthesis of prolactin, and the analog dibutyryl cyclic AMP increases the production of both hormones.


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