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American Zoologist 1975 15(2):279-284; doi:10.1093/icb/15.2.279
© 1975 by The Society for Integrative and Comparative Biology
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In vitro Demonstration of Lactogenic Activity in the Mammalian Placenta

FRANK TALMANTES, JR.
Department of Zoology and Cancer Research Laboratory, University of California Berkeley, California 94720

As part of a comparative study of the occurrence of placental prolactins among mammals, studies were done to see if the placentae of a variety of mammals produce a prolactin, and if it is produced, during what period of gestation it is demonstrable. The lactogenic activity of baboon, sheep, chinchilla, hamster, mouse, rat, and rabbit placentae at different stages of pregnancy were examined by organ co-culture of placental explants with prelactating mammary tissue, as well as by the addition of placental extracts to mammary organ cultures. The lactogenic activity of human placental lactogen (hPL) was also examined. Mammary tissue from nulliparous (day 11 or 12) pregnant BALB/c Crgl mice were cultured in Waymouth's synthetic medium supplimented with insulin (5 µg/ml) and aldosterone (1 µg/ml). The lactogenic activity of the baboon, sheep, chinchilla, hamster, rat, and mouse placentae was clearly demonstrable. In the rabbit, the lactogenic activity was not detectable.


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