Skip Navigation

American Zoologist 1977 17(3):577-584; doi:10.1093/icb/17.3.577
© 1977 by The Society for Integrative and Comparative Biology
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by SEECOF, R. L.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

A Genetic Approach to the Study of Neurogenesis and Myogenesis

ROBERT L. SEECOF
Department of Developmental Biology, City of Hope National Medical Center Duarte, California, 91010

Extensive sequences of morphological differentiation have been described for Drosophila melanogaster neurogenesis and myogenesis. Neuroblasts and myoblasts become determined in the blastoderm or shortly thereafter. Each blast cell will then morphologically differentiate in vitro in sequences that closely resemble the events in vivo. Functional neurons, muscle cells and neuromuscular junctions form and these have normal biochemical and ultrastructural characteristics. A mutant hunt was conducted which was designed to generate mutations specific to neurogenesis or myogenesis. One mutation was recovered that apparently interfered only with myogenesis. The frequency of recovered mutations that affected cell differentiation was low and led to estimates that relatively few genes are required to preserve the structural integrity of cells during neurogenesis and myogenesis.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.