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American Zoologist 1981 21(2):535-548; doi:10.1093/icb/21.2.535
© 1981 by The Society for Integrative and Comparative Biology
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Tumor Gene Expression and Interphase Chromatin Appearance in Xiphophorus1

FRITZ ANDERS, KAMALESH CHATTERJEE, MANFRED SCHWAB, EBERHARD SCHOLL and ANNEROSE ANDERS
Genetisches Institut der Justus-Liebig-Universilat Giessen D-6300 Giessen, Federal Republic of Germany

SYNOPSIS. Xiphophorus maculatus (platyfish) exhibits spots which consist of neoplastically transformed pigment cells (T-cells). The spots actually represent extreme benign melanomas. Transformation to T-cells is mediated by a "tumor gene" (Tu). Platyfish which develop from X-irradiated embryos reveal an increase of Tu-expression resulting in an overproduction of T-cells to benign melanomas which can be compared to that observed in certain hybrids between the platyfish and Xiphophorus helleri (swordtail). Both the X irradiation-induced and the crossing conditioned increase of Tu-expression represent a heritable alteration which might be related to a conversion from dispersed to condensed chromatin in the interphase nuclei.


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