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American Zoologist 1983 23(3):541-549; doi:10.1093/icb/23.3.541
© 1983 by The Society for Integrative and Comparative Biology
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Early Events in the Interaction of Melanotropin with Cloudman S91 Melanoma Cells1

DREW T. LAMBERT
Department of Dermatology, School of Medicine, Yale University New Haven, Connecticut 06510

Melanotropin stimulates melanin synthesis in Cloudman S91 melanoma cells, the accumulation of melanin being preceded by a number of events which are understood to various degrees. In this review I will discuss the control of melanogenesis by melanotropin; emphasis will be on the early events of the process, although other aspects will be discussed. The probes (fluorescent and radioactive labels) used to examine the binding of the hormone to the cells will be described, as will be the results of initial binding studies. One of the events immediately following the binding of the hormone is the activation of adenylate cyclase: the evidence supporting this, plus the role of cyclic AMP in stimulating melanin synthesis, will be discussed. Also examined is the role which internalization of the melanotropin-receptor-adenylate cyclase complex may play in mediating hormone action.


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