Skip Navigation

American Zoologist 1984 24(3):563-570; doi:10.1093/icb/24.3.563
© 1984 by The Society for Integrative and Comparative Biology
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by BELLAIRS, R.
Right arrow Articles by VAN PETEGHEM, M.-C.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Gastrulation: Is It Analogous to Malignant Invasion1

RUTH BELLAIRS and MARIE-CHRISTINE VAN PETEGHEM
Department of Anatomy and Embryology, University College London Gower Street, London WC1 6BT, U.K
Loboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine University Hospital De Pintelaan 185, B-900 Gent, Belgium

The process of gastrulation has often been compared with that of malignant invasion. In this paper, the terms "malignant" and "invasion" are denned and the characteristics of malignant cells are discussed. One of the best examples of invasion during gastrulation takes place during the formation of the endoderm in the chick, when the definitive endoblast invades the hypoblast. Experiments are described in which the hypoblast is invaded by a) definitive endoblast, b) other normal embryonic cells, and c) three types of human malignant cells. It was found that not only does the hypoblast react differently to normal and malignant cells, but that the cell interactions differ also according to the type of malignant cells. In particular, there are differences in the behaviour of the cells and in the amount of extracellular material laid down between the hypoblast and malignant cells. It is concluded that even within the limits of this experiment, chick gastrulation is not wholly analogous to malignant invasion.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.