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American Zoologist 1989 29(2):605-616; doi:10.1093/icb/29.2.605
© 1989 by The Society for Integrative and Comparative Biology
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The Yeast Saccharomyces cerevisiae in Molecular and Cellular Biology: A Smaller but not Lower Eucaryote1

JASPER RINE
Department of Biochemistry, University of California Berkeley, California 94720

The baker's yeast Saccharomyces cerevisiae is a single celled eucaryote that is gaining appeal for studies of fundamental processes in cellular and molecular biology. This article describes three examples of the use of yeast to study problems of importance to human medicine. Specifically, the enzymes involved in neuropeptide processing, the RAS oncogenes, and the regulation of cholesterol biosynthesis in humans are shown to have remarkable similarities to their equivalent processes in yeast. In several cases the yeast and human enzymes are functionally interchangeable, emphasizing the unity of basic principles in biology.


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