Skip Navigation

American Zoologist 1994 34(3):305-312; doi:10.1093/icb/34.3.305
© 1994 by The Society for Integrative and Comparative Biology
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by LYONS, G. E.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Expression of Myogenic Factor Genes in Vertebrate Embryos1

GARY E. LYONS
Department of Anatomy, University of Wisconsin Medical School, 1300 University Avenue Madison, Wisconsin 53706

SYNOPSIS. In situ hybridization analyses of the developmental patterns of expression of the members of the MyoD family of myogenic regulatory factors have been carried out in several vertebrate species. Differences between the temporal sequence of appearance of these gene transcripts seen in mouse embryos and those detected in avian and in Xenopus embryos suggest that these transcription factors may serve overlapping or redundant functions. Targeted inactivation of two myogenic factor genes in the mouse supports this hypothesis. These factors appear to be necessary but may not be sufficient for muscle-specific gene activation during embryogenesis. The distinct spatial and temporal patterns of gene activation and transcript accumulation of the four related factors in mouse embryos as detected by in situ hybridization are reviewed and discussed in the context of the embryological origins and developmental patterning of muscle in somites and in limb buds. These results are compared briefly with those on myogenic factor gene expression patterns in chick, quail and Xenopus embryos


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.