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American Zoologist 2000 40(3):402-411; doi:10.1093/icb/40.3.402
© 2000 by The Society for Integrative and Comparative Biology
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Endocrine Disruption and Developmental Abnormalities of Female Reproduction1

Taisen Iguchi2,1 and Tomomi Sato2
1 Center for Integrative Bioscience, Okazaki National Research Institutes, 38 Nishigonaka, Myodaiji, Okazaki 444-8585, Japan, Department of Biology and Graduate School of Integrated Science, Yokohama City University, Kanazawa-ku, Yokohama 236-0027, Japan, CREST, Japan Science and Technology Corporation
2 Department of Biology and Graduate School of Integrated Science, Yokohama City University, Kanazawa-ku, Yokohama 236-0027, Japan

The developing organism is particularly sensitive to exposure to estrogenic chemicals during a critical period in the induction of longterm changes in female reproductive organs, and persistent molecular alterations induced by the perinatal estrogenic agents. The perinatal mouse model can be utilized as an indicator of possible longterm consequences of exposure to exogenous estrogenic compounds including environmental endocrine disruptors. Attention should be paid to abnormalities in female genital organs exposed to estrogenic endocrine disruptors during fetal and early postnatal development in mammals including humans.


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