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American Zoologist 2001 41(3):389-398; doi:10.1093/icb/41.3.389
© 2001 by The Society for Integrative and Comparative Biology
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Limb Regeneration in the Fiddler Crab, Uca pugilator: Hormonal and Growth Factor Control1

Penny M. Hopkins2,1
1 Department of Zoology, University of Oklahoma, Norman, Oklahoma 73019

This paper summarizes recent work on various aspects of hormonal control of regeneration in the crustacean, Uca pugilator. Hormonal control in this crab is effected by means of the crustactean steroid hormones, the ecdysteroids. New evidence is presented supporting a role for the retinoid hormones, all-trans retinoic acid and 9-cis retinoic acid, in the control of regeneration in these animals. The possible role of fibroblast growth factors in organization of the limb blastema is explored and the similarities between vertebrate and invertebrate control of regeneration are discussed.


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