Skip Navigation

Integrative and Comparative Biology 2002 42(4):725-735; doi:10.1093/icb/42.4.725
© 2002 by The Society for Integrative and Comparative Biology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (9)
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Sutton, M. A.
Right arrow Articles by Carew, T. J.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Behavioral, Cellular, and Molecular Analysis of Memory in Aplysia I: Intermediate-Term Memory1

Michael A. Sutton1,2 and Thomas J. Carew2,2
1 Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06520-8074
2 Department of Neurobiology and Behavior, University of California Irvine, Irvine, California 92697-4550

Serotonin (5HT) induces short-term and long-term synaptic facilitation (STF and LTF, respectively) at sensory neuron to motor neuron (SN-MN) synapses in Aplysia, and these forms of plasticity are thought to contribute to short-term and long-term memory for behavioral sensitization. Recent evidence in Aplysia has identified a third phase of synaptic facilitation—intermediate-term facilitation (ITF)—that is temporally and mechanistically distinct from STF and LTF. Here, we review the findings of recent studies that have examined this unique intermediate-term phase at molecular, cellular, and behavioral levels. The results indicate that, at tail SN-MN synapses, multiple forms of ITF can be distinguished; they are induced via distinct mechanisms and use parallel molecular pathways for their expression. Moreover, we have incorporated the temporal and molecular features of these different forms of ITF at tail SN-MN synapses into behavioral analyses, and found that they accurately predict distinct forms of intermediate-term memory for sensitization of the tail-elicited siphon withdrawal reflex. These findings indicate that different types of experiences engage distinct molecular pathways in the service of memory retention over the same time domain.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
D. Fulton, M. C. Condro, K. Pearce, and D. L. Glanzman
The Potential Role of Postsynaptic Phospholipase C Activity in Synaptic Facilitation and Behavioral Sensitization in Aplysia
J Neurophysiol, July 1, 2008; 100(1): 108 - 116.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
G. P. McNally, K. A. Augustyn, and R. Richardson
GABAA receptors determine the temporal dynamics of memory retention
Learn. Mem., February 19, 2008; 15(3): 106 - 111.
[Abstract] [Full Text] [PDF]

Home page
 Integr. Comp. Biol.Home page
F. B. Krasne and D. H. Edwards
Modulation of the Crayfish Escape Reflex--Physiology and Neuroethology
Integr. Comp. Biol., August 1, 2002; 42(4): 705 - 715.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.