Integrative and Comparative Biology Advance Access originally published online on August 30, 2007
Integrative and Comparative Biology 2007 47(4):552-577; doi:10.1093/icb/icm072
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From critters to cancers: bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia
*Department of Biology and Center for Molecular Phylogeny and Evolution, Ghent University, B-9000, Ghent, Belgium; Oregon Institute of Marine Biology and Department of Biology, University of Oregon, Charleston, OR 97420, USA; Department of Molecular and Cellular Pharmacology and the Vascular Biology Institute, University of Miami Medical Center, Miami, FL 33136, USA; Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA 50011, USA; ¶Environmental Science Division, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Horinouchi, Hachioji, Tokyo 192-0392, Japan; ||Institute of Molecular Genetics, University of Mainz, D-55099 Mainz, Germany; #Institute of Animal Physiology, University of Hamburg, D-20146 Hamburg, Germany; **Centre of Excellence in Evolutionary Genetics and Physiology, Department of Biology, University of Turku, FI-20014 Turku, Finland; Alfred-Wegener Institute for Polar and Marine Research, Physiology of Marine Animals, D-27570 Bremerhaven, Germany; Institut für Physiologie, Universität Duisburg-Essen, D-45122 Essen, Germany; Renal Section, Hammersmith Campus, Imperial College London, London W12 0NN, UK; ¶¶Division of Molecular Medicine, Department of Laboratory Medicine, Lund University, University Hospital MAS, SE-205 02 Malmö, Sweden; ##Institute of Veterinary Physiology, Vetsuisse Faculty and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, CH-8057 Zurich, Switzerland
Correspondence: 1E-mail: tgorr{at}access.uzh.ch
The objective of this symposium at the First International Congress of Respiratory Biology (ICRB) was to enhance communication between comparative biologists and cancer researchers working on O2 sensing via the HIF pathway. Representatives from both camps came together on August 13–16, 2006, in Bonn, Germany, to discuss molecular adaptations that occur after cells have been challenged by a reduced (hypoxia) or completely absent (anoxia) supply of oxygen. This brief "critters-to-cancer" survey discusses current projects and new directions aimed at improving understanding of hypoxic signaling and developing therapeutic interventions.
This paper summarizes one of the 22 symposia that constituted the "First International Congress of Respiratory Biology" held August 14–16, 2006, in Bonn, Germany.
The first two authors and the last author contributed equally as editors to this article.