Skip Navigation

American Zoologist 1966 6(1):21-31; doi:10.1093/icb/6.1.21
© 1966 by The Society for Integrative and Comparative Biology
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by YAMADA, T.
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Control of Tissue Specificity: The Pattern of Cellular Synthetic Activities in Tissue Transformation1

TUNEO YAMADA
Biology Division, Oak Ridge National Laboratory Oak Ridge, Tennessee

During transformation of the dorsal marginal iris into lens tissue after removal of the lens in the adult newt, the cells undergo gradual changes in synthetic activities. Autoradiographic data indicate an enhancement of RNA synthesis in the nucleus of iris cells, which is followed by enhancement of protein synthesis and onset ot DNA synthesis. After discharge of pigment granules and a period of cellular multiplication accompanied by ribosome production, the cells stop DNA synthesis and start to show detectable amounts of lens-specific proteins ({alpha}-,ß-, and {gamma}-crystallins). This time coincides with initiation of differentiation of primary lens fibers. In the later stages of regeneration, {alpha}- and ß-crystallins are present in the dividing cells of the lens epithelium, as well as in the cells of the fiber area, but {gamma}-crystallins are detected only in Che cells of the fiber area. The data were interpreted as suggesting that the gene utilization pattern typical for the iris is not directly converted into that for the lens, but goes through intermediate patterns before the tissue transformation is completed.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.