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American Zoologist 1968 8(2):273-284; doi:10.1093/icb/8.2.273
© 1968 by The Society for Integrative and Comparative Biology
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Cellular Interactions in Morphogenesis of the Thyroid Gland

S. Robert Hilfer
Department of Biology, Temple University Philadelphia, Pennsylvania, 19122

The existence of an epithelio-mesodermal interaction in the embryonic chick thyroid has been tested by reaggregation of 8- and 16-day epithelial monolayers with capsule, mesentery, heart ventricle, and perichondrial cells. Establishment of the histological anil cytological pattern of the thyroid occurred only in the presence of capsule. The loss of endoplasmic reticulum which occurs in monolayer culture was shown not to be a result of spreading, since organ cultures of immediately reaggregated cells undergo the same degenerative changes. Dissociation itself also cannot be the explanation for the loss since membrane destruction and recovery occur at different times in raft cultures and in chorio-allantoic grafts. The similarity of the results after immediate reaggregation and in combinations of epithelial cells with capsule after monolayer culture suggests that the role of the mesodermal component is to support the specialized cytoplasmic structure and function of the epithelial cell type.


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