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American Zoologist 1968 8(2):285-305; doi:10.1093/icb/8.2.285
© 1968 by The Society for Integrative and Comparative Biology
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Retention of Differentiated Function in Clonal Animal Cell Lines, Particularly Hormone-Secreting Cultures

Yosihiro Yasumura
Graduate Department of Biochemistry, Brandeis University Walthum, Massachusetts, 02154

Clonal hormone-secreting cell lines have been established from animal tumors. These lines include adrenal steroid-secreting cells, growth hormone-secreting cells, steroid-secreting Leydig cells, and ACTH-secreting cells that retain their differentiated function for prolonged periods in continuous culture. In addition, fibroblast cell lines that secrete a material which stimulates steroidogenesis by adrenal cells and Leydig cells are described. A systematic approach to obtain functional cultures and the general problem of retention of differentiated function in cultured cells are discussed.


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