Integrative and Comparative Biology Advance Access published online on June 28, 2008
Integrative and Comparative Biology, doi:10.1093/icb/icn065
Historical hypotheses regarding segmentation of the vertebrate head
Neurobiology Unit, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093-0201, USA; Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0201, USA
Correspondence: 1E-mail: rgnorthcutt{at}ucsd.edu
The morphology of the vertebrate head is extremely complex and comprises numerous iterative structures that arise from each of the embryonic germ layers. The search for a fundamental plan uniting all of these serial structures spans 
200 years. The earliest attempt to identify a common plan was J. W. Goethe's vertebral theory of skull organization, in which the skull was interpreted as being formed by a series of trunk vertebrae. This theory was rejected by T. H. Huxley in the 1858 Croonian Lecture and was replaced by the segmented mesodermal model of Francis Balfour, which was elaborated subsequently by A. Marshall, Gavin de Beer, and Edwin Goodrich. This model assumes that the head of the earliest vertebrates consisted of eight segments. It further assumes that each segment contained dorsal muscles arising from the somitic mesoderm, and ventral muscles arising from lateral plate mesoderm, except for the first segment, which lacked ventral muscles derived from the lateral plate mesoderm. The muscles of each head segment were believed to be innervated by two pairs of cranial nerves, homologous to the dorsal and ventral spinal nerves of lampreys. The validity of this theory, known as the Goodrich model, came into question, however, after the discovery that the branchiomeric muscles associated with each pharyngeal arch do not arise from lateral plate mesoderm, as initially proposed by Marshall and subsequently accepted by Goodrich and de Beer, but, rather, arise from paraxial mesoderm. Furthermore, segmentation of the brain into some 14 neuromeres cannot be accommodated by any model involving eight segments. Finally, there is also clear evidence that at least one, if not two, additional series of placodally derived sensory nerves occurs in the head and has no counterpart in the trunk. At present, there is no theory of segmentation that can account for all cephalic iterative structures.
From the symposium "Vertebrate Head Segmentation in a Modern Evo-Devo Context" presented at the annual meeting of the Society for Integrative and Comparative Biology, January 2–6, 2008, at San Antonio, Texas.