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American Zoologist 2000 40(2):223-233; doi:10.1093/icb/40.2.223
© 2000 by The Society for Integrative and Comparative Biology
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Fish Insulin, IGF-I and IGF-II Receptors: A Phylogenetic Approach1

Josep V. Planas2,1, Eva Méndez1, Nuria Baños1, Encarnación Capilla1, Juan Castillo1, Isabel Navarro1 and Joaquim Gutiérrez1
1 Departament de Fisiologia, Facultat de Biologia, Universitat de Barcelona, Avda. Diagonal 645, 08028 Barcelona, Spain

In fish, the structural and functional characteristics of insulin and IGF-I receptors have been well studied. Current evidence indicates that all gnatostome animals, from fish to mammals, contain separate insulin and IGF-I molecules and specific receptors for insulin and IGF-I. However, qualitative differences in the functional aspects of insulin and IGF-I receptors among vertebrate species can account for variations in the biological activity of insulin and IGF-I. In this paper we will focus on the functional evolution of the insulin and IGF-I receptors in vertebrates and on the appearance of the unrelated IGF-II receptors.


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