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Integrative and Comparative Biology Advance Access originally published online on April 28, 2008
Integrative and Comparative Biology 2008 48(4):505-511; doi:10.1093/icb/icn024
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© The Author 2008. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oxfordjournals.org.

Characterization, chromosomal location, and genomic neighborhood of a ratite ortholog of a gene with gonadal expression in mammals

Daniel E. Janes1,*, Tariq Ezaz{dagger}, Jennifer A. Marshall Graves{dagger} and Scott V. Edwards*
*Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; {dagger}Comparative Genomics Group, Research School of Biological Sciences, Australian National University, PO Box 475, Canberra ACT 2601, Australia

Correspondence: 1E-mail: djanes{at}oeb.harvard.edu

A locus that we name SubA was discovered during large-scale sequencing and characterization of a bacterial artificial chromosome library from an emu, Dromaius novaehollandiae. This locus yields a significantly negative Tajima's D in emus and is conserved across emu, chicken, mouse, and human. Expression of SubA orthologs has been reported in human ovaries and in mouse testes, but remains unknown in emus. The locus was physically mapped onto a pair of microchromosomes in emus by fluorescent in situ hybridization and also in chicken as previously reported. By characterizing emu SubA in this article, we aim to improve current descriptions of the cascade of genes associated with avian sex differentiation. Future experimentation will report the expression of SubA in ratites, other birds, and nonavian reptiles.

From the symposium "Reptile Genomics and Evolutionary Genetics" presented at the annual meeting of the Society for Integrative and Comparative Biology, January 2–6, 2008, at San Antonio, Texas.


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