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Integrative and Comparative Biology Advance Access published online on March 29, 2006
Integrative and Comparative Biology, doi:10.1093/icb/icj030
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© The Society for Integrative and Comparative Biology 2006. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Complex Life-Histories in Marine Benthic Invertebrates: A Symposium in Memory of Larry McEdward

The evolution of embryonic gene expression in sea urchins

Gregory A. Wray 1 *
1 Department of Biology, Duke University, Box 90338, Durham, NC 27708-0338, USA

* To whom correspondence should be addressed.
Gregory A. Wray, E-mail: gwray{at}duke.edu


  Abstract

Synopsis Many evolutionary modifications in development and life history derive from changes in embryonic gene expression. However, the genetic variation affecting gene expression in natural populations is not well understood, nor are the evolutionary mechanisms that operate on that variation. The early embryonic gene network of the purple sea urchin (Strongylocentrotus purpuratus) has been studied in considerable detail, providing an informative basis for analyzing the developmental and evolutionary mechanisms that alter gene expression. Comparative functional analyses have been carried out for several genes. These case studies indicate a complex relationship between sequence divergence and gene expression: in some cases, gene expression is conserved despite extensive divergence in cis-regulatory sequences, while in others the basis for a change in gene expression does not reside locally but rather in the expression or activity of transcription factors that regulate its expression. Diverse evolutionary mechanisms apparently operate on cis-regulatory regions, including negative, balancing, and stabilizing selection.

From the symposium "Complex Life-Histories in Marine Benthic Invertebrates: A Symposium in Memory of Larry McEdward" presented at the annual meeting of the Society for Integrative and Comparative Biology, January 4-8, 2005, at San Diego, CA.
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