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Integrative and Comparative Biology Advance Access published online on October 11, 2006
Integrative and Comparative Biology, doi:10.1093/icb/icl048
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© The Author 2006. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oxfordjournals.org.

Ecological Immunology: Recent Advances and Applications for Conservation and Public Health

Arsenic ecotoxicology and innate immunity

Christopher R. Lage 1, Akshata Nayak 1, and Carol H. Kim 1 *
1 Department of Biochemistry, Microbiology and Molecular Biology, University of Maine, Orono, ME 04469, USA

* To whom correspondence should be addressed.
Carol H. Kim, E-mail: carolkim{at}maine.edu


  Abstract

Synopsis Understanding the ecotoxicological effects of arsenic in the environment is paramount to mitigating its deleterious effects on ecological and human health, particularly on the immune response. Toxicological and long-term health effects of arsenic exposure have been well studied. Its specific effects on immune function, however, are less well understood. Eukaryotic immune function often includes both general (innate) as well as specific (adaptive) responses to pathogens. Innate immunity is thought to be the primary defense during early embryonic development, subsequently potentiating adaptive immunity in jawed vertebrates, whereas all other eukaryotes must rely solely on the innate immune response throughout their life cycle. Here, we review the known ecotoxicological effects of arsenic on general health, including immune function, and propose the adoption of zebrafish as a vertebrate model for studying such effects on innate immunity.

From the symposium "Ecological Immunology: Recent Advances and Applications for Conservation and Public Health" presented at the annual meeting of the Society for Integrative and Comparative Biology, January 4-8, 2006, at Orlando, Florida.
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 Toxicol SciHome page
A. S. Nayak, C. R. Lage, and C. H. Kim
Effects of Low Concentrations of Arsenic on the Innate Immune System of the Zebrafish (Danio Rerio)
Toxicol. Sci., July 1, 2007; 98(1): 118 - 124.
[Abstract] [Full Text] [PDF]


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